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Contacts between the commissural axons and the floor plate cells are mediated by nectins.

Authors: Okabe, N  Shimizu, K  Ozaki-Kuroda, K  Nakanishi, H  Morimoto, K  Takeuchi, M  Katsumaru, H  Murakami, F  Takai, Y 
Citation: Okabe N, etal., Dev Biol. 2004 Sep 15;273(2):244-56.
Pubmed: (View Article at PubMed) PMID:15328010
DOI: Full-text: DOI:10.1016/j.ydbio.2004.05.034

During development of the central nervous system (CNS), commissural axons grow toward the ventral midline. After crossing the floor plate, they abruptly change their trajectory from the circumferential to the longitudinal axis. The contacts between the commissural axons and the floor plate cells are involved in this axonal guidance, but their mechanisms or structures have not fully been understood. In this study, we found that nectin-1 and -3, immunoglobulin-like cell-cell adhesion molecules, asymmetrically localized at the contact sites between the commissural axons and the floor plate cells, respectively. In vitro perturbation of the endogenous trans-interaction between nectin-1 and -3 caused abnormal fasciculation of the commissural axons and impairment of the contacts, and resulted in failure in longitudinal turns of the commissural axons at the contralateral sites of the rat hindbrain. These results indicate that the contacts between the commissural axons and the floor plate cells are mediated by the hetero-trans-interaction between nectin-1 and -3 and involved in regulation of the trajectory of the commissural axons.

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CRRD Object Information
CRRD ID: 1599806
Created: 2007-02-15
Species: All species
Last Modified: 2007-02-15
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.