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Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma.

Authors: Lekanne Deprez, RH  Riegman, PH  Groen, NA  Warringa, UL  Van Biezen, NA  Molijn, AC  Bootsma, D  De Jong, PJ  Menon, AG  Kley, NA 
Citation: Lekanne Deprez RH, etal., Oncogene. 1995 Apr 20;10(8):1521-8.
Pubmed: (View Article at PubMed) PMID:7731706

We have isolated a gene, called MN1, which resides on chromosome 22 and which was found to be disrupted by a balanced translocation (4;22) in meningioma 32. The MN1 gene spans about 70 kb and consists of at least two large exons of approximately 4.7 kb and 2.8 kb. The MN1 cDNA codes for a protein of 1319 amino acids when the first methionine in the open reading frame is used. The MN1 cDNA contains two CAG repeats, one of which codes for a string of 28 glutamines. The t(4;22) disrupts the 5'-exon within the open reading frame. In meningioma 32 no expression of the MN1 mRNA is observed. These results suggest that inactivation of the MN1 gene in this tumour may contribute to its pathogenesis.

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CRRD Object Information
CRRD ID: 1600423
Created: 2007-03-08
Species: All species
Last Modified: 2007-03-08
Status: ACTIVE



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