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bcr-abl RNA in patients with chronic myelogenous leukemia.

Authors: Shtivelman, E  Gale, RP  Dreazen, O  Berrebi, A  Zaizov, R  Kubonishi, I  Miyoshi, I  Canaani, E 
Citation: Shtivelman E, etal., Blood. 1987 Mar;69(3):971-3.
Pubmed: (View Article at PubMed) PMID:3101769

The major consequence of the formation of the Philadelphia (Ph1) chromosome characteristic of leukemia cells of patients with chronic myelogenous leukemia (CML) is fusion of c-abl and bcr genes. Using a sensitive RNase protection technique, we analyzed mRNA from a large number of CML patients. In most, we identified one or both species of bcr-abl chimeric transcripts. These two mRNAs vary in the specific bcr exon joined to abl exon II and are translated into slightly different proteins. The amounts of the fused mRNA within leukemia cells vary considerably between individuals and do not correlate with the phase of the disease.


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CRRD Object Information
CRRD ID: 1600510
Created: 2007-03-12
Species: All species
Last Modified: 2007-03-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.