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Hypothalamic melanocortin system regulates sympathetic nerve activity in brown adipose tissue.

Authors: Yasuda, T  Masaki, T  Kakuma, T  Yoshimatsu, H 
Citation: Yasuda T, etal., Exp Biol Med (Maywood). 2004 Mar;229(3):235-9.
Pubmed: (View Article at PubMed) PMID:14988515

To clarify the neuronal mechanism of the hypothalamic melanocortin system in regulating energy metabolism, we investigated the effects of centrally administered alpha-melanocyte-stimulating hormone (alpha-MSH) and agouti-related protein (AGRP), an agonist and an antagonist for the melanocortin 4 receptor (MC4-R), respectively, on the activity of sympathetic nerves innervating brown adipose tissue (BAT) and on BAT temperature. A bolus infusion of alpha-MSH (1 nmol) into the third cerebral ventricle (i3vt) significantly increased sympathetic nerve activity and elevated BAT temperature (P<0.05). The i3vt infusion of AGRP (1 nmol) gradually suppressed BAT sympathetic nerve activity and was accompanied by a significant reduction in BAT temperature (P<0.05). In conclusion, the hypothalamic melanocortin system may regulate peripheral energy expenditure, as well as thermogenesis, through its influence on BAT sympathetic nerve activity.

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CRRD Object Information
CRRD ID: 1600780
Created: 2007-03-27
Species: All species
Last Modified: 2007-03-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.