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Growth hormone-releasing hormone and pituitary somatotrope proliferation.

Authors: Frohman, LA  Kineman, RD 
Citation: Frohman LA and Kineman RD, Minerva Endocrinol. 2002 Dec;27(4):277-85.
Pubmed: (View Article at PubMed) PMID:12511850

Growth hormone-releasing hormone (GHRH) is a hypothalamic hormone that is essential for normal expansion of the somatotrope lineage during pituitary development. Decreased GHRH secretion and/or action leads to impairment of this process and somatotrope hypoplasia in both humans and experimental animals. Excessive GHRH secretion and/or action result in dysregulated somatotrope proliferation, leading to hyperplasia and neoplastic transformation. Our understanding of the molecular and morphologic bases for these effects from both animal and clinical studies has greatly increased during the past decade. However, many features of the cellular pathways remain to be defined, including the interaction of other genes in the multistep process of somatotrope tumorigenesis.


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CRRD Object Information
CRRD ID: 1601329
Created: 2007-04-17
Species: All species
Last Modified: 2007-04-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.