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Heme oxygenase-1 inhibits cytokine production by activated mast cells.

Authors: Yasui, Y  Nakamura, M  Onda, T  Uehara, T  Murata, S  Matsui, N  Fukuishi, N  Akagi, R  Suematsu, M  Akagi, M 
Citation: Yasui Y, etal., Biochem Biophys Res Commun. 2007 Mar 9;354(2):485-90. Epub 2007 Jan 10.
Pubmed: (View Article at PubMed) PMID:17234154
DOI: Full-text: DOI:10.1016/j.bbrc.2006.12.228

Heme oxygenase-1 (HO-1) is thought to contribute to host defense reactions against various stresses. In addition, recent reports have suggested that HO-1 modulates immunocyte activation and functions. HO-1 suppresses mast cell degranulation, but whether HO-1 suppresses cytokine synthesis as well is not yet known. We examined whether rat HO-1 cDNA transfected rat basophilic leukemia (RBL)-2H3 cells have altered cytokine production in response to stimulation with anti-ovalbumin (OA) serum/OA compared to Mock transfected RBL-2H3 cells. HO-1 inhibited anti-OA serum/OA-induced IL-3 and TNF-alpha production. Inhibition of HO-1 activity by Zn (II) protoporphyrin IX, a specific HO-1 inhibitor, prevented the suppression of TNF-alpha production. The cytokine inhibition by HO-1 was associated with selective suppression of the DNA-binding activity of AP-1 transcription factors. The suppression of mast cell cytokine production by HO-1 may be an important aspect of the processes that lead to resolution of allergic inflammation.


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CRRD Object Information
CRRD ID: 1601626
Created: 2007-04-26
Species: All species
Last Modified: 2007-04-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.