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IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity.

Authors: Sosa, L  Dupraz, S  Laurino, L  Bollati, F  Bisbal, M  Caceres, A  Pfenninger, KH  Quiroga, S 
Citation: Sosa L, etal., Nat Neurosci. 2006 Aug;9(8):993-5. Epub 2006 Jul 16.
Pubmed: (View Article at PubMed) PMID:16845384
DOI: Full-text: DOI:10.1038/nn1742

How a neuron becomes polarized remains largely unknown. Results obtained with a function-blocking antibody and an siRNA targeting the insulin-like growth factor-1 (IGF-1) receptor suggest that an essential step in the establishment of hippocampal neuronal polarity and the initiation of axonal outgrowth is the activation of the phosphatidylinositol 3-kinase (PI3k)-Cdc42 pathway by the IGF-1 receptor, but not by the TrkA or TrkB receptors.

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CRRD Object Information
CRRD ID: 1624300
Created: 2007-05-08
Species: All species
Last Modified: 2007-05-08
Status: ACTIVE



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