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Molecular genetics of meningiomas.

Authors: Ragel, BT  Jensen, RL 
Citation: Ragel BT and Jensen RL, Neurosurg Focus. 2005 Nov 15;19(5):E9.
Pubmed: (View Article at PubMed) PMID:16398473

In this article the authors provide a brief description of the current understanding of meningioma genetics. Chromosome 22 abnormalities, especially in the Neurofibromatosis Type 2 (NF2) gene, have been associated with meningioma development. Loss of heterozygosity of chromosome 22 occurs in approximately 60% of meningiomas; however, loss of NF2 gene function occurs in only one third of these lesions. This discrepancy supports the theory that a second tumor suppressor gene exists on chromosome 22, and the authors introduce several possible gene candidates, including BAM22, LARGE, INI1, and MN1 genes. Deletions of 1p have also been shown to correlate with meningioma progression. The genetic similarities and differences among sporadic, NF2-associated, pediatric, and radiation-induced meningiomas are discussed, with the observation that the nonsporadic meningiomas have a higher incidence of multiple chromosomal abnormalities at presentation. Ultimately, a better understanding of the molecular pathways of meningioma tumorigenesis will lead to new, successful treatments.

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CRRD Object Information
CRRD ID: 1624321
Created: 2007-05-08
Species: All species
Last Modified: 2007-05-08
Status: ACTIVE



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