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Decreased antioxidant activity in hypercholesterolemic children with nephrotic syndrome.

Authors: Zachwieja, J  Bobkowski, W  Dobrowolska-Zachwieja, A  Zaniew, M  Maciejewski, J 
Citation: Zachwieja J, etal., Med Sci Monit. 2003 Jun;9(6):CR235-9.
Pubmed: (View Article at PubMed) PMID:12824952

BACKGROUND: The aim of the present study was to estimate the total antioxidant status (TAS) and main antioxidant enzyme activity in children with nephrotic syndrome (NS). MATERIAL/METHODS: The study was carried out in a group of 82 children with NS, age 4-16 years (mean 7.4). Of these, 59 with a first episode formed group I, and 23 children in remission (>6 months, with no immunosuppressive treatment) formed group II. TAS was estimated using the two-reagent Randox Total Antioxidant Status test in plasma. RESULTS: TAS was significantly reduced in group I compared to controls (0.77+/-0.14 mmol/l vs. 1.18+/-0.42 mmol/l; p<0.001). The TAS level was more reduced in those patients with higher total cholesterol (TChol) and low density lipoproteins cholesterol (LDL-cholesterol). In children from group I the activity of glutathione reductase (GR) was lower than in the controls (8.10+/-2.40 U/g Hb vs. 10.55+/-3.81 U/g Hb, p<0.001) and similarly the activity of glutathione peroxidase (GPX) was lower in group I compared to controls (28.65+/-6.99 U/g Hb vs. 33.84+/-13.11 U/g Hb, p=0.010). There was no significant difference in superoxide dismutase (SOD) activity between the 3 groups. CONCLUSIONS: Reduced antioxidant activity may be related to lipid abnormalities in NS.

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CRRD Object Information
CRRD ID: 1625122
Created: 2007-05-22
Species: All species
Last Modified: 2007-05-22
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.