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Effects of rat fetuin on stimulation of bone resorption in the presence of parathyroid hormone.

Authors: Nakamura, O  Kazi, JA  Ohnishi, T  Arakaki, N  Shao, Q  Kajihara, T  Daikuhara, Y 
Citation: Nakamura O, etal., Biosci Biotechnol Biochem. 1999 Aug;63(8):1383-91.
Pubmed: (View Article at PubMed) PMID:10500999
DOI: Full-text: DOI:10.1271/bbb.63.1383

Rat fetuin, which is the rat counterpart of human alpha 2-HS glycoprotein and bovine fetuin, is only detectable in calcified tissues such as bone matrices and dentin, and bone cells such as osteoblasts and osteocytes immunohistochemically. The effect of this protein on bone resorption was examined to study its physiological role in bone metabolism. Rat fetuin increased bone resorption in the presence of low concentrations of parathyroid hormone (PTH), but it had no activity on bone resorption without PTH. The increase in bone resorption by PTH and PTH plus rat fetuin was inhibited by the addition of chymostatin, an inhibitor for cathepsin L. Moreover, we found that when type I collagen from rat was preincubated with rat fetuin, the digestion of rat type I collagen by cathepsin L was increased. These findings suggest that rat fetuin present in bone matrix is important in bone resorption.


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CRRD Object Information
CRRD ID: 1625797
Created: 2007-07-05
Species: All species
Last Modified: 2007-07-05
Status: ACTIVE


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