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Insulin increases expression of apobec-1, the catalytic subunit of the apolipoprotein B mRNA editing complex in rat hepatocytes.

Authors: Von Wronski, MA  Hirano, KI  Cagen, LM  Wilcox, HG  Raghow, R  Thorngate, FE  Heimberg, M  Davidson, NO  Elam, MB 
Citation: von Wronski MA, etal., Metabolism. 1998 Jul;47(7):869-73.
Pubmed: (View Article at PubMed) PMID:9667237

We have previously shown that chronic insulin treatment of rat hepatocytes increases the fraction of edited apolipoprotein B (apoB) mRNA from approximately 50% to as much as 90%. We have now examined the effect of insulin on apobec-1 mRNA abundance and demonstrate that increased editing of apoB mRNA following insulin treatment is accompanied by elevated apobec-1 mRNA levels in primary rat hepatocytes. Time-course measurements of the effects of insulin on apoB mRNA editing and apobec-1 mRNA abundance showed that both were elevated almost maximally within 48 hours and sustained for at least 5 days of insulin treatment.

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CRRD Object Information
CRRD ID: 1626288
Created: 2007-07-30
Species: All species
Last Modified: 2007-07-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.