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Upregulation of intracardiac adrenomedullin and its receptor system in rats with volume overload-induced cardiac hypertrophy.

Authors: Yoshihara, F  Nishikimi, T  Okano, I  Hino, J  Horio, T  Tokudome, T  Suga, S  Matsuoka, H  Kangawa, K  Kawano, Y 
Citation: Yoshihara F, etal., Regul Pept. 2005 Apr 15;127(1-3):239-44.
Pubmed: (View Article at PubMed) PMID:15680493
DOI: Full-text: DOI:10.1016/j.regpep.2004.12.017

Specific adrenomedullin receptors have been identified as calcitonin receptor-like receptor (CRLR)/receptor activity-modifying proteins (RAMP2 and RAMP3) complexes. Although we have demonstrated that adrenomedullin is increased in volume overload-induced cardiac hypertrophy, it remains unknown whether the adrenomedullin receptor is altered or not. This study sought to investigate the significance of intracardiac adrenomedullin and its receptor system in volume overload-induced cardiac hypertrophy. Left ventricular adrenomedullin levels were higher in aortocaval shunt (ACS) rats than in controls (+58%). The left ventricular gene expressions of adrenomedullin, CRLR, RAMP2 and RAMP3 were increased (+27%, +76%, +108% and +131%, respectively) and the left ventricular collagen gene expressions were also increased (type I: +138%, type III: +87%). The left ventricular adrenomedullin level correlated with the gene expression of type III collagen (R=0.42). These results suggest that intracardiac adrenomedullin and its receptor system are upregulated and may participate in the regulation of cardiac remodeling in volume overload-induced cardiac hypertrophy.


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CRRD Object Information
CRRD ID: 1642686
Created: 2007-10-09
Species: All species
Last Modified: 2007-10-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.