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Altered expression of Smad family members in injured motor neurons of rat.

Authors: Okuyama, N  Kiryu-Seo, S  Kiyama, H 
Citation: Okuyama N, etal., Brain Res. 2007 Feb 9;1132(1):36-41. Epub 2006 Dec 12.
Pubmed: (View Article at PubMed) PMID:17166487
DOI: Full-text: DOI:10.1016/j.brainres.2006.11.019

We examined changes in the expression of Smad family members, which transduce signals from TGF-beta superfamily ligands, following hypoglossal nerve injury. RT-PCR and in situ hybridization revealed that Smad1, 2, 3 and 4 mRNAs were significantly up-regulated in injured side, whereas Smad8 mRNA was down-regulated. Immunohistochemistry and Western blotting analysis confirmed the alterations of Smad1, 2 and 4 in injured neurons. These results suggest that the Smad signaling may be important for nerve regeneration.

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CRRD Object Information
CRRD ID: 1643227
Created: 2007-12-17
Species: All species
Last Modified: 2007-12-17
Status: ACTIVE



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