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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.

Authors: Engelman, JA  Luo, J  Cantley, LC 
Citation: Engelman JA, etal., Nat Rev Genet. 2006 Aug;7(8):606-19.
Pubmed: (View Article at PubMed) PMID:16847462
DOI: Full-text: DOI:10.1038/nrg1879

Phosphatidylinositol 3-kinases (PI3Ks) evolved from a single enzyme that regulates vesicle trafficking in unicellular eukaryotes into a family of enzymes that regulate cellular metabolism and growth in multicellular organisms. In this review, we examine how the PI3K pathway has evolved to control these fundamental processes, and how this pathway is in turn regulated by intricate feedback and crosstalk mechanisms. In light of the recent advances in our understanding of the function of PI3Ks in the pathogenesis of diabetes and cancer, we discuss the exciting therapeutic opportunities for targeting this pathway to treat these diseases.

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CRRD Object Information
CRRD ID: 2290476
Created: 2008-03-13
Species: All species
Last Modified: 2008-03-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.