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Definition of a 1.06-Mb region linked to neuroinflammation in humans, rats and mice.

Authors: Ockinger, J  Serrano-Fernandez, P  Moller, S  Ibrahim, SM  Olsson, T  Jagodic, M 
Citation: Ockinger J, etal., Genetics. 2006 Jul;173(3):1539-45. Epub 2006 Apr 19.
Pubmed: (View Article at PubMed) PMID:16624898
DOI: Full-text: DOI:10.1534/genetics.106.057406

Unbiased identification of susceptibility genes might provide new insights into pathogenic mechanisms that govern complex inflammatory diseases such as multiple sclerosis. In this study we fine mapped Eae18a, a region on rat chromosome 10 that regulates experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. We utilized two independent approaches: (1) in silico mapping based on sequence similarity between human multiple sclerosis susceptibility regions and rodent EAE quantitative trait loci and (2) linkage mapping in an F10 (DA x PVG.AV1) rat advanced intercrossed line. The linkage mapping defines Eae18a to a 5-Mb region, which overlaps one intergenomic consensus region identified in silico. The combined approach confirms experimentally, for the first time, the accuracy of the in silico method. Moreover, the shared intersection between the results of both mapping techniques defines a 1.06-Mb region containing 13 candidate genes for the regulation of neuroinflammation in humans, rats, and mice.

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CRRD Object Information
CRRD ID: 2293859
Created: 2008-06-17
Species: All species
Last Modified: 2008-06-17
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.