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Serum tissue inhibitor of metalloproteinase-2 (TIMP-2) and matrix metalloproteinase-2 in complex with the inhibitor (MMP-2:TIMP-2) as prognostic markers in bladder cancer.

Authors: Vasala, K  Turpeenniemi-Hujanen, T 
Citation: Vasala K and Turpeenniemi-Hujanen T, Clin Biochem. 2007 Jun;40(9-10):640-4. Epub 2007 Feb 8.
Pubmed: (View Article at PubMed) PMID:17374529
DOI: Full-text: DOI:10.1016/j.clinbiochem.2007.01.021

OBJECTIVES: To examine whether the circulating TIMP-2 or MMP-2:TIMP-2 complex associate with disease-free or cause-specific survival in bladder cancer patients. DESIGN AND METHODS: Levels of circulating TIMP-2 and MMP-2:TIMP-2 complex from 50 patients and 44 healthy volunteers were measured by ELISA and compared with the clinical data. RESULTS: In cancer patients the levels of TIMP-2 and MMP-2:TIMP-2 complex were significantly lower than in healthy volunteers (p= or <0.0001). Low TIMP-2 levels and low MMP-2:TIMP-2 complex levels correlated significantly with poor prognosis (p=0.0032, p=0.0022, respectively). The 5-year cause-specific survival rate was 67% and 60% in patients with a high serum level for TIMP-2 and MMP-2:TIMP-2 versus 18% and 20% in those with low levels of TIMP-2 and MMP-2:TIMP-2 complex. CONCLUSIONS: The results indicate that TIMP-2 and MMP-2:TIMP-2 complex associate with favorable clinical course and could be used as a novel prognostic indicators in bladder cancer.


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CRRD Object Information
CRRD ID: 2298521
Created: 2008-07-07
Species: All species
Last Modified: 2008-07-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.