VEGF receptor signalling - in control of vascular function.

Authors: Olsson, AK  Dimberg, A  Kreuger, J  Claesson-Welsh, L 
Citation: Olsson AK, etal., Nat Rev Mol Cell Biol. 2006 May;7(5):359-71.
Pubmed: (View Article at PubMed) PMID:16633338
DOI: Full-text: DOI:10.1038/nrm1911

Vascular endothelial growth-factor receptors (VEGFRs) regulate the cardiovascular system. VEGFR1 is required for the recruitment of haematopoietic precursors and migration of monocytes and macrophages, whereas VEGFR2 and VEGFR3 are essential for the functions of vascular endothelial and lymphendothelial cells, respectively. Recent insights have shed light onto VEGFR signal transduction and the interplay between different VEGFRs and VEGF co-receptors in development, adult physiology and disease.


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CRRD Object Information
CRRD ID: 2298727
Created: 2008-07-18
Species: All species
Last Modified: 2008-07-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.