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Haplotypic structure across the I kappa B alpha gene (NFKBIA) and association with multiple myeloma.

Authors: Spink, CF  Gray, LC  Davies, FE  Morgan, GJ  Bidwell, JL 
Citation: Spink CF, etal., Cancer Lett. 2007 Feb 8;246(1-2):92-9. Epub 2006 Mar 15.
Pubmed: (View Article at PubMed) PMID:16540234
DOI: Full-text: DOI:10.1016/j.canlet.2006.02.001

Polymorphisms in NFKBIA may be important in pre-disposition to and outcome after treatment, of multiple myeloma (MM). The NFKBIA gene product, IkappaBalpha, binds to NF-kappaB preventing its activation and is important in mediating resistance to apoptosis in B-cell lymphoproliferative diseases. This study investigates eight polymorphisms across the NFKBIA gene in large patient and control populations. Significant differences in the frequency of particular polymorphisms were noted between patients and controls. A risk haplotype [GCCTATCA] for MM was also identified (P=0.006). Analysis of the genetics of NFKBIA may lead to associations with disease progression and survival and thus more personalized therapy.

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CRRD Object Information
CRRD ID: 2298898
Created: 2008-07-31
Species: All species
Last Modified: 2008-07-31
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.