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Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFkappaB) inhibitor in rat microglia.

Authors: Nakajima, K  Matsushita, Y  Tohyama, Y  Kohsaka, S  Kurihara, T 
Citation: Nakajima K, etal., Neurosci Lett. 2006 Jul 3;401(3):199-202. Epub 2006 Mar 31.
Pubmed: (View Article at PubMed) PMID:16580131
DOI: Full-text: DOI:10.1016/j.neulet.2006.03.014

The molecular mechanism by which the deleterious cytokines interleukin 1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha) are induced in endotoxin-stimulated microglia was investigated from the viewpoint of signal transduction. Neither cytokine is produced in nonstimulated rat microglia, but both are remarkably induced by stimulation with endotoxin lipopolysaccharide (LPS). LPS-inducible IL-1beta was significantly suppressed by pretreatment with the nuclear factor kappa B (NFkappaB) inhibitor ammonium pyrrolidine dithiocarbamate (APDC), but TNFalpha was not. APDC was actually confirmed to suppress the degradation of IkappaBalpha and IkappaBbeta in microglia, indicating a role for the inhibitor of NFkappaB activation. Taken together, these results suggest that the induction of IL-1beta and TNFalpha in endotoxin-stimulated microglia is differentially regulated at the level of NFkappaB activation.


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CRRD Object Information
CRRD ID: 2298917
Created: 2008-07-31
Species: All species
Last Modified: 2008-07-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.