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Effect of administration of galactosamine hydrochloride on rat liver mitochondria.

Authors: Padma, P  Setty, OH 
Citation: Padma P and Setty OH, Indian J Biochem Biophys. 1997 Jun;34(3):296-301.
Pubmed: (View Article at PubMed) PMID:9425749

The effect of galactosamine on liver mitochondrial functions was studied in vivo in rats at 12hr, 24hr and 36hr after the administration of the drug. State 3 respiration decreased significantly with both NAD+ linked and FAD linked substrates. Respiratory control ratio, an index of membrane integrity and P/O ratio which is a measure of phosphorylation efficiency decreased significantly. There was a significant decrease in the activities of NADH dehydrogenase, succinate dehydrogenase and cytochrome oxidase. A significant decrease was also seen on membrane potential, cytochrome aa3, cytochrome b, cytochrome c and on phospholipids of mitochondria. The observed mitochondrial dysfunctions were related to increased lipid peroxidation, which could cause loss of membrane integrity and a decreased rate of phosphorylation. It is proposed that increased lipid peroxidation was responsible for the inhibition on both oxidation and phosphorylation in mitochondria in galactosamine treated rats.

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CRRD Object Information
CRRD ID: 2298960
Created: 2008-08-06
Species: All species
Last Modified: 2008-08-06
Status: ACTIVE



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