Cerebrospinal fluid levels of neurofilament light in chronic experimental autoimmune encephalomyelitis.

Authors: Norgren, N  Edelstam, A  Stigbrand, T 
Citation: Norgren N, etal., Brain Res Bull. 2005 Oct 30;67(4):264-8.
Pubmed: (View Article at PubMed) PMID:16182933
DOI: Full-text: DOI:10.1016/j.brainresbull.2005.06.031

Experimental autoimmune encephalomyelitis (EAE) induced by myelin oligodendrocyte glycoprotein (MOG) is a chronic relapsing-remitting animal model of multiple sclerosis (MS). Neurofilament light (NF-L), a structural protein expressed in neuronal cells can be used to quantify the amount of neuronal damage in MS patients. An immunoassay was used to measure levels of neurofilament light in cerebrospinal fluid (CSF) in rats with myelin oligodendrocyte glycoprotein-induced EAE. Significantly increased levels of neurofilament were found in the immunized animals compared to the controls, strengthening the similarities in the diseases and the progression pattern between the animal model and MS. The turnover of NF-L during this disease is increased since significantly elevated levels also were identified in the spinal cord of the diseased animals and immunohistochemistry gave support for this observation. Monitoring neurofilament levels in EAE can be used to follow disease progression and effects of therapy.


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CRRD Object Information
CRRD ID: 2299007
Created: 2008-08-08
Species: All species
Last Modified: 2008-08-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.