The Met tyrosine kinase receptor in development and cancer.

Authors: Gentile, A  Trusolino, L  Comoglio, PM 
Citation: Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
Pubmed: (View Article at PubMed) PMID:18175071
DOI: Full-text: DOI:10.1007/s10555-007-9107-6

Met is a tyrosine kinase receptor, encoded by an oncogene, whose crucial role has been elucidated during the last two decades. The complex biological program triggered by Met has been dissected and its biological relevance in both physiology and pathology has been proven. Met supports a morphogenetic program, known as invasive growth, taking place both during embryogenesis and adulthood. In tumors Met is often aberrantly activated, giving rise to the pathological counterpart of the invasive growth program: cancer progression towards metastasis. Several approaches have been recently developed to interfere with the tumorigenic and metastatic processes triggered by Met.


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CRRD Object Information
CRRD ID: 2299174
Created: 2008-08-15
Species: All species
Last Modified: 2008-08-15
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.