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Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in rats.

Authors: Asahina, M  Haruyama, W  Ichida, Y  Sakamoto, M  Sato, M  Imaizumi, K 
Citation: Asahina M, etal., J Lipid Res. 2008 Aug 27.
Pubmed: (View Article at PubMed) PMID:18753676
DOI: Full-text: DOI:10.1194/jlr.M800135-JLR200

We have previously mapped a diet-induced hypercholesterolemia locus (Dihc2) to chromosome 14 in the F2 generation crossed of high-responsive exogenous hypercholesterolemia rats and low-responsive BN rats. To identify a causal gene within this locus, we constructed interval-specific congenic lines (ISCLs) and carried out expression and sequencing analyses. Here we narrowed Dihc2 to region including 33 genes and predicted transcripts and identified RGD1309450_predicted, a homologous gene of SMEK2, as a strong candidate for responsiveness to dietary cholesterol. Our finding provides new insights into the pathway underlying the individual responsiveness to dietary cholesterol in vivo.


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CRRD Object Information
CRRD ID: 2300117
Created: 2008-09-05
Species: All species
Last Modified: 2008-09-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.