Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma.

Authors: Ramakrishnan, G  Elinos-Baez, CM  Jagan, S  Augustine, TA  Kamaraj, S  Anandakumar, P  Devaki, T 
Citation: Ramakrishnan G, etal., Mol Cell Biochem. 2008 Jun;313(1-2):53-61. Epub 2008 Mar 31.
Pubmed: (View Article at PubMed) PMID:18373278
DOI: Full-text: DOI:10.1007/s11010-008-9741-5

Silymarin is a naturally available bioflavonoid and is a strong antioxidant with a capacity to inhibit the formation of tumors in several cancer models. In the present study, we investigated whether dietary supplementation of silymarin has any role in lipid components, lipid-metabolizing enzymes, free fatty acid profile, and expression of cyclooxygenase-2 (COX-2) in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinoma in rats. NDEA-induced rats showed severe hyperlipidemia along with upregulated expression of COX-2 as revealed by western blotting and immunohistochemistry. Dietary silymarin supplementation attenuated this hyperlipidemia and downregulated the expression of COX-2. Thus we conclude that compounds like silymarin with potent hypolipidemic effect are strong candidates as chemopreventive agents for the treatment of liver cancer.

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CRRD Object Information
CRRD ID: 2300283
Created: 2008-09-10
Species: All species
Last Modified: 2008-09-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.