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ILK, PINCH and parvin: the tIPP of integrin signalling.

Authors: Legate, KR  Montanez, E  Kudlacek, O  Fassler, R 
Citation: Legate KR, etal., Nat Rev Mol Cell Biol. 2006 Jan;7(1):20-31.
Pubmed: (View Article at PubMed) PMID:16493410
DOI: Full-text: DOI:10.1038/nrm1789

The ternary complex of integrin-linked kinase (ILK), PINCH and parvin functions as a signalling platform for integrins by interfacing with the actin cytoskeleton and many diverse signalling pathways. All these proteins have synergistic functions at focal adhesions, but recent work has indicated that these proteins might also have separate roles within a cell. They function as regulators of gene transcription or cell-cell adhesion.


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Additional Information

CRRD Object Information
CRRD ID: 2300344
Created: 2008-09-12
Species: All species
Last Modified: 2008-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.