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Acetylcholinesterase and choline uptake in striatum from rats with varying sleeping times.

Authors: Chumakova, OV  Liopo, AV 
Citation: Chumakova OV and Liopo AV, Alcohol Alcohol. 1996 Mar;31(2):217-20.
Pubmed: (View Article at PubMed) PMID:8737018

Male rats were injected with ethanol as a 25% solution (3.5 g/kg body weight) and then the duration of the retention of the righting reflex (DRR) as well as the duration of ethanol-induced sleep (DEIS) were recorded. On the basis of DEIS in 60 rats, we selected four groups of six rats each: short-sleep group (SS, 34 +/- 5 min), intermediate-sleep (IS, 118 +/- 3 min), long-sleep (LS, 186 +/- 5 min) and non-sleep rats (NS, 0 min). The striatal crude mitochondrial fraction was assayed for acetylcholinesterase activity (AChE, EC and high-affinity choline uptake. NS rats manifested similarity of the above parameters to those determined in SS and IS rats. LS rats were distinguished by a higher AChE activity in comparison with NS animals.


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CRRD Object Information
CRRD ID: 2301207
Created: 2008-09-30
Species: All species
Last Modified: 2008-09-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.