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Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes.

Authors: Bicknell, KA  Coxon, CH  Brooks, G 
Citation: Bicknell KA, etal., Biochem J. 2004 Sep 1;382(Pt 2):411-6.
Pubmed: (View Article at PubMed) PMID:15253691
DOI: Full-text: DOI:10.1042/BJ20031481

Repair of the mature mammalian myocardium following injury is impaired by the inability of the majority of cardiomyocytes to undergo cell division. We show that overexpression of the cyclin B1-CDC2 (cell division cycle 2 kinase) complex re-initiates cell division in adult cardiomyocytes. Thus strategies targeting the cyclin B1-CDC2 complex might re-initiate cell division in mature cardiomyocytes in vivo and facilitate myocardial regeneration following injury.


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CRRD Object Information
CRRD ID: 2301353
Created: 2008-10-07
Species: All species
Last Modified: 2008-10-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.