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The genetics of cardiovascular disease.

Authors: Delles, C  McBride, MW  Padmanabhan, S  Dominiczak, AF 
Citation: Delles C, etal., Trends Endocrinol Metab. 2008 Sep 24.
Pubmed: (View Article at PubMed) PMID:18819818
DOI: Full-text: DOI:10.1016/j.tem.2008.07.010

Recent advances in genotyping technology and insights into disease mechanisms have increased interest in the genetics of cardiovascular disease. Several candidate genes involved in cardiovascular diseases were identified from studies using animal models, and the translation of these findings to human disease is an exciting challenge. There is a trend towards large-scale genome-wide association studies that are subject to strict quality criteria with regard to both genotyping and phenotyping. Here, we review some of the strategies that have been developed to translate findings from experimental models to human disease and outline the need for optimizing global approaches to analyze such results. Findings from ongoing studies are interpreted in the context of disease pathways instead of the more traditional focus on single genetic variants.


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CRRD Object Information
CRRD ID: 2301356
Created: 2008-10-08
Species: All species
Last Modified: 2008-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.