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The profile of cardiac cytochrome c oxidase (COX) expression in an accelerated cardiac-hypertrophy model.

Authors: Kuo, WW  Chu, CY  Wu, CH  Lin, JA  Liu, JY  Ying, TH  Lee, SD  Hsieh, YH  Chu, CH  Lin, DY  Hsu, HH  Huang, CY 
Citation: Kuo WW, etal., J Biomed Sci. 2005;12(4):601-10. Epub 2005 Nov 10.
Pubmed: (View Article at PubMed) PMID:16132109
DOI: Full-text: DOI:10.1007/s11373-005-7373-2

The contribution of the mitochondrial components, the main source of energy for the cardiac hypertrophic growth induced by pressure overload, is not well understood. In the present study, complete coarctation of abdominal aorta was used to induce the rapid development of cardiac hypertrophy in rats. One to two days after surgery, we observed significantly higher blood pressure and cardiac hypertrophy, which remained constantly high afterwards. We found an early increased level of cytochrome c oxidase (COX) mRNA determined by in-situ hybridization and dot blotting assays in the hypertrophied hearts, and a drop to the baseline 20 days after surgery. Similarly, mitochondrial COX protein level and enzyme activity increased and, however, dropped even lower than baseline 20 days following surgery. In addition, in natural hypertension-induced hypertrophic hearts in genetically hypertensive rats, the COX protein was significantly lower than in normotensive rats. Taken together, the lower efficiency of mitochondrial activity in the enlarged hearts of long-term complete coarcted rats or genetically hypertensive rats could be, at least partially, the cause of hypertensive cardiac disease. Additionally, the rapid complete coarctation-induced cardiac hypertrophy was accompanied by a disproportionate COX activity increase, which was suggested to maintain the cardiac energy-producing capacity in overloaded hearts.

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CRRD Object Information
CRRD ID: 2301377
Created: 2008-10-09
Species: All species
Last Modified: 2008-10-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.