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Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma.

Authors: Torng, PL  Lee, YC  Huang, CY  Ye, JH  Lin, YS  Chu, YW  Huang, SC  Cohen, P  Wu, CW  Lin, CT 
Citation: Torng PL, etal., Oncogene. 2008 Apr 3;27(15):2137-47. Epub 2007 Oct 22.
Pubmed: (View Article at PubMed) PMID:17952116
DOI: Full-text: DOI:10.1038/sj.onc.1210864

Metastasis and invasion occur in the majority of epithelial ovarian carcinoma at diagnosis. To delineate the molecular signature in ovarian cancer invasion, we established and characterized a human ovarian endometrioid carcinoma (EC) cell line OVTW59-P0 and its invasion-related sublines (P1-P4, in the order of increasing invasive activity). P4 showed faster migration and larger xenograft formation with metastasis than P0. By microarray analysis of different gene expression among P0-P4 sublines, one group of gene was found negatively correlated with cancer invasion. Among these genes, IGFBP-3 was identified as one of the most remarkably suppressed gene that showed lower gene expression in P4 than P0. Re-expression of IGFBP-3 in P4 effectively inhibited cell migration, invasion and metastasis, but did not affect cell proliferation. In 35 patients with EC tumors, low IGFBP-3 expression correlated clinically with higher tumor grade, advanced stage and poor survival. Our results provide evidence and indicate that IGFBP-3 plays an important role as an invasion-metastasis suppressor in ovarian EC.


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CRRD Object Information
CRRD ID: 2301465
Created: 2008-10-16
Species: All species
Last Modified: 2008-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.