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Developmental changes in the folate-dependent enzymes of de novo purine biosynthesis in rat brain.

Authors: Dominguez, J  Ordonez, LA 
Citation: Dominguez J and Ordonez LA, J Neurochem. 1982 Mar;38(3):625-30.
Pubmed: (View Article at PubMed) PMID:7057182

The activities of the two folate-dependent enzymes in the de novo purine biosynthetic pathway (e.g., glycinamide ribonucleotide transformylase and aminoimidazolecarboxamide ribonucleotide transformylase), have been evaluated as a function of age in crude extracts from rat brain, liver, kidney, and spleen. The activities of the enzymes in brain are similar to those found in liver and kidney. In all tissues the activity of both enzymes was higher during early development, more than nine times above adult levels. In the CNS the enzymatic activities are apparently related to the periods of increased nucleic acid synthesis, with different activities being found in different regions during development. Our findings lend strong support to the suggestion that folic acid-dependent metabolism plays an important role during early development of the brain.


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CRRD Object Information
CRRD ID: 2301991
Created: 2008-11-13
Species: All species
Last Modified: 2008-11-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.