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Cloning and characterization of the rat 5-HT5B receptor. Evidence that the 5-HT5B receptor couples to a G protein in mammalian cell membranes.

Authors: Wisden, W  Parker, EM  Mahle, CD  Grisel, DA  Nowak, HP  Yocca, FD  Felder, CC  Seeburg, PH  Voigt, MM 
Citation: Wisden W, etal., FEBS Lett. 1993 Oct 25;333(1-2):25-31.
Pubmed: (View Article at PubMed) PMID:8224165

A gene encoding a novel G protein-coupled 5-hydroxytryptamine (5-HT) receptor, termed 5-HT5B, was cloned. The ligand binding profile of this receptor is distinct from that of other cloned 5-HT receptors. The 5-HT5B receptor couples to a G protein in COS1 cell membranes; however, activation of the 5-HT5B receptor does not appear to alter either cAMP accumulation or phosphoinositide turnover in a variety of fibroblast cell lines. In the rat brain, 5-HT5B gene expression occurs predominantly in the medial habenulae and hippocampal CA1 cells of the adult. Little expression is seen during embryonic development.


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CRRD Object Information
CRRD ID: 2303647
Created: 2009-02-20
Species: All species
Last Modified: 2009-02-20
Status: ACTIVE


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