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The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats.

Authors: Clark, L  Greenbaum, C  Jiang, J  Lernmark, A  Ochs, H 
Citation: Clark L, etal., FEMS Immunol Med Microbiol. 2002 Feb 18;32(3):205-9.
Pubmed: (View Article at PubMed) PMID:11934565

Congenic BioBreeding (BB) rats, homozygous for the autosomal lymphopenia (Lyp) gene (Lyp/Lyp), heterozygous (Lyp/+), or wild-type (+/+), were immunized with the T cell-dependent bacteriophage PhiX174 to determine effects of Lyp on primary and secondary antibody responses. The primary PhiX174 antibody response did not differ between the three different genotypes. In contrast, the secondary immune response, expressed as the peak neutralizing titer, was markedly reduced in Lyp/Lyp (9.9+/-3.2; mean value+/-S.E.M. for seven rats) compared to both Lyp/+ (51+/-12; n=13; P=0.006) and +/+ (100+/-20; n=7; P=0.004) BB rats. We suggest that the secondary antibody response to the T cell-dependent neoantigen PhiX174 is linked in a recessive manner to genetic factor(s) in the Lyp gene region.


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CRRD Object Information
CRRD ID: 2303774
Created: 2009-02-26
Species: All species
Last Modified: 2009-02-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.