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Glucose has to be phosphorylated to activate glycogen synthase, but not to inactivate glycogen phosphorylase in hepatocytes.

Authors: Carabaza, A  Ciudad, CJ  Baque, S  Guinovart, JJ 
Citation: Carabaza A, etal., FEBS Lett. 1992 Jan 20;296(2):211-4.
Pubmed: (View Article at PubMed) PMID:1733780

2-Deoxyglucose and 5-thioglucose, in the same fashion as glucose, cause the inactivation of the rat hepatocyte glycogen phosphorylase and the activation of glycogen synthase. However, 6-deoxyglucose and 1,5-anhydroglucitol inactivate phosphorylase without increasing the activation state of glycogen synthase. With 3-O-methylglucose no changes in the activity of these enzymes occurred. These results prove that while glucose is the molecule that triggers the inactivation of phosphorylase, glucose 6-phosphate is the signal for glucose synthase activation and that a metabolite control of the activation state of glycogen synthase is operative in hepatocytes.


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CRRD Object Information
CRRD ID: 2304117
Created: 2009-03-06
Species: All species
Last Modified: 2009-03-06
Status: ACTIVE


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