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Interleukin 6 mediated differentiation and rescue of cell redox in PC12 cells exposed to ionizing radiation.

Authors: Abeyama, K  Kawano, K  Nakajima, T  Takasaki, I  Kitajima, I  Maruyama, I 
Citation: Abeyama K, etal., FEBS Lett. 1995 May 15;364(3):298-300.
Pubmed: (View Article at PubMed) PMID:7538937

The differentiation of PC12 cells to a neuron-like morphology was induced by ionizing radiation in the presence of serum. This effect was detectable at 5 grays (Gy) and reached a maximum at 10-20 Gy. Increases in the DNA binding activity of nuclear factor kappa B (NF-kappa B) and increased Interleukin 6 (IL-6) mRNA levels were observed at a dose of 15 Gy. Neutralization of supernatant IL-6 by the addition of anti-IL-6 antibody inhibited the neuronal differentiation and decreased cellular redox. Ionizing radiation and serum may act synergistically as neurotropic factors.


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CRRD Object Information
CRRD ID: 2306944
Created: 2009-05-12
Species: All species
Last Modified: 2009-05-12
Status: ACTIVE


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