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Changes in annexin I and II levels during the postnatal development of rat pancreatic islets.

Authors: Ohnishi, M  Tokuda, M  Masaki, T  Fujimura, T  Tai, Y  Matsui, H  Itano, T  Ishida, T  Takahara, J  Konishi, R 
Citation: Ohnishi M, etal., J Cell Sci. 1994 Aug;107 ( Pt 8):2117-25.
Pubmed: (View Article at PubMed) PMID:7527053

The expression patterns and the dynamic changes in content of both annexin I and annexin II in the rat pancreatic islets during postnatal development were investigated by both western blot analysis and immunohistochemistry. Immunohistochemical methods clearly demonstrated the presence of annexins I and II exclusively in pancreatic islets, while exocrine tissues were not stained by anti-annexin antibodies. Pancreatic islets were diffusely stained with no specific differences in distribution between different cell types. The expression of annexin I in pancreatic islets gradually increased with postnatal development. A developmental study of annexins I and II by western blot analysis essentially supported the results obtained by immunohistochemistry. In addition, the increasing expression of two protein tyrosine kinases, epidermal growth factor-receptor/kinase and pp60src, which phosphorylate annexin I and annexin II, respectively, and of protein kinase C, which phosphorylates both proteins, was also shown during postnatal development in rat pancreatic islets. Thus, a relationship between the expression of annexins I and II and the maturation of islet cell function is suggested.


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CRRD Object Information
CRRD ID: 2306957
Created: 2009-05-12
Species: All species
Last Modified: 2009-05-12
Status: ACTIVE


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