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Subclinical inflammation and diabetic polyneuropathy: MONICA/KORA Survey F3 (Augsburg, Germany).

Authors: Herder, C  Lankisch, M  Ziegler, D  Rathmann, W  Koenig, W  Illig, T  Doring, A  Thorand, B  Holle, R  Giani, G  Martin, S  Meisinger, C 
Citation: Herder C, etal., Diabetes Care. 2009 Apr;32(4):680-2. Epub 2009 Jan 8.
Pubmed: (View Article at PubMed) PMID:19131463
DOI: Full-text: DOI:10.2337/dc08-2011

OBJECTIVE: Subclinical inflammation represents a risk factor of type 2 diabetes and several diabetes complications, but data on diabetic neuropathies are scarce. Therefore, we investigated whether circulating concentrations of acute-phase proteins, cytokines, and chemokines differ among diabetic patients with or without diabetic polyneuropathy. RESEARCH DESIGN AND METHODS: We measured 10 markers of subclinical inflammation in 227 type 2 diabetic patients with diabetic polyneuropathy who participated in the population-based MONICA/KORA Survey F3 (2004-2005; Augsburg, Germany). Diabetic polyneuropathy was diagnosed using the Michigan Neuropathy Screening Instrument (MNSI). RESULTS: After adjustment for multiple confounders, high levels of C-reactive protein and interleukin (IL)-6 were most consistently associated with diabetic polyneuropathy, high MNSI score, and specific neuropathic deficits, whereas some inverse associations were seen for IL-18. CONCLUSIONS: This study shows that subclinical inflammation is associated with diabetic polyneuropathy and neuropathic impairments. This association appears rather specific because only certain immune mediators and impairments are involved.


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CRRD Object Information
CRRD ID: 2307274
Created: 2009-05-26
Species: All species
Last Modified: 2009-05-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.