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Autoantibodies against CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) that impair glucose-induced insulin secretion in noninsulin- dependent diabetes patients.

Authors: Ikehata, F  Satoh, J  Nata, K  Tohgo, A  Nakazawa, T  Kato, I  Kobayashi, S  Akiyama, T  Takasawa, S  Toyota, T  Okamoto, H 
Citation: Ikehata F, etal., J Clin Invest. 1998 Jul 15;102(2):395-401.
Pubmed: (View Article at PubMed) PMID:9664081
DOI: Full-text: DOI:10.1172/JCI1656

Cyclic ADP-ribose (cADPR) has been shown to be a mediator for intracellular Ca2+ mobilization for insulin secretion by glucose in pancreatic beta cells, and CD38 shows both ADP-ribosyl cyclase to synthesize cADPR from NAD+ and cADPR hydrolase to hydrolyze cADPR to ADP-ribose. We show here that 13.8% of Japanese non-insulin-dependent diabetes (NIDDM) patients examined have autoantibodies against CD38 and that the sera containing anti-CD38 autoantibodies inhibit the ADP-ribosyl cyclase activity of CD38 (P

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CRRD Object Information
CRRD ID: 2307276
Created: 2009-05-26
Species: All species
Last Modified: 2009-05-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.