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Syndecan-2 overexpression regulates adhesion and migration through cooperation with integrin alpha2.

Authors: Choi, S  Kim, Y  Park, H  Han, IO  Chung, E  Lee, SY  Kim, YB  Lee, JW  Oh, ES  Yi, JY 
Citation: Choi S, etal., Biochem Biophys Res Commun. 2009 Jun 26;384(2):231-5. Epub 2009 Apr 24.
Pubmed: (View Article at PubMed) PMID:19394307
DOI: Full-text: DOI:10.1016/j.bbrc.2009.04.093

Syndecan-2, a transmembrane heparan sulfate proteoglycan, is known to serve as an adhesion receptor, but details of the regulatory mechanism governing syndecan-2 cell adhesion and migration remain unclear. Here, we examined this regulatory mechanism, showing that overexpression of syndecan-2 enhanced collagen adhesion, cell migration and invasion of normal rat intestinal epithelial cells (RIE1), and increased integrin alpha2 expression levels. Interestingly, RIE1 cells transfected with either syndecan-2 or integrin alpha2 showed similar adhesion and migration patterns, and a function-blocking anti-integrin alpha2 antibody abolished syndecan-2-mediated adhesion and migration. Consistent with these findings, transfection of integrin alpha2 siRNA diminished syndecan-2-induced cell migration in HCT116 human colon cancer cells. Taken together, these results demonstrate a novel cooperation between syndecan-2 and integrin alpha2beta1 in adhesion-mediated cell migration and invasion. This interactive dynamic might be a possible mechanism underlying the tumorigenic activities of colon cancer cells.


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CRRD Object Information
CRRD ID: 2307393
Created: 2009-06-01
Species: All species
Last Modified: 2009-06-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.