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[Effects of quercetin and enalapril on amount of PDGF-B and VEGF-1 in kidney of diabetic rats]

Authors: Huang, H  Fu, J  Tian, H 
Citation: Huang H, etal., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2005 Aug;22(4):791-4.
Pubmed: (View Article at PubMed) PMID:16156274

This study sought to assess the effects of Quercetin and Enalapril on urinary protein excretion and amount of platelet-derived growth factor-B (PDGF-B) and vascular endothelial growth factor-1 (VEGF-1) in renal tissue of diabetic rats. 29 streptozotocin-induced diabetic rats were divided into 3 groups, diabetic control group (group D, n=12); Enalapril group (group E, n=10); Quercetin group (group Q, n=7). In addition, there was one normal control group (group N, n = 5). The urinary protein excretion of 24 hours was measured at 4, 8, 12 weeks. All rats were sacrificed at 12 weeks. The amounts of PDGF-B and VEGF-1 in renal tissue were measured by immunohistochemical techniques. The 24-h levels of urinary protein excretion of D,Q and E groups were higher than that of N group; the level of Q, E groups were lower than that of D group; there was no difference between Q and E group. The expression levels of PDGF-B and VEGF-1 in renal tissue of D, Q, and E groups were significantly higher than that of N group the levels of Q and E groups were significantly lower than that of D group, no difference was found between Q and E group. The protective role of Quercetin and Enalapril in lowering urinary protein excretion may be related to the decreased amounts of PDGF-B and VEGF-1 in renal tissue.

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CRRD Object Information
CRRD ID: 2311653
Created: 2009-07-28
Species: All species
Last Modified: 2009-07-28
Status: ACTIVE



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