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Hexapeptides HLDF-6 and PEDF-6 restore memory in rats after chronic intracerebroventricular treatment with beta-amyloid peptide Abeta(25-35).

Authors: Storozheva, ZI  Proshin, AT  Zhokhov, SS  Sherstnev, VV  Rodionov, IL  Lipkin, VM  Kostanyan, IA 
Citation: Storozheva ZI, etal., Bull Exp Biol Med. 2006 Mar;141(3):319-22.
Pubmed: (View Article at PubMed) PMID:17073149

Effects of homologous peptides HLDF-6 and PEDF-6 on behavior of animals with experimental Alzheimer's disease induced by chronic intracerebroventricular administration of beta-amyloid peptide Abeta(25-35) were studied in the zoosocial recognition test and Morris water maze. Peptides HLDF-6 and PEDF-6 possessed neuroprotective activity and counteracted the toxic effect of Abeta(25-35). Peptides HLDF-6 and PEDF-6 mainly improved long-term memory and working memory, respectively.


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CRRD Object Information
CRRD ID: 2312353
Created: 2009-08-07
Species: All species
Last Modified: 2009-08-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.