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Genetic mapping found major QTLs for antibody-induced glomerulonephritis in WKY rats.

Authors: Kose, H  Sado, Y  Yamada, T  Matsumoto, K 
Citation: Kose H, etal., Exp Anim. 2009 Apr;58(2):193-8.
Pubmed: (View Article at PubMed) PMID:19448344

Genetic bases of glomerulonephritis, a major cause of kidney dysfunction in humans and one of the most characteristic complications of autoimmune disorders such as Goodpasture syndrome, are complex. The Wistar-Kyoto (WKY) rat strain is well characterized for its susceptibility to autoantibodies against glomerular basement membrane (GBM), however the molecular mechanisms underlining the phenotype are largely unknown. Here we performed a whole genome scan using a backcross (BC) F(1) (WKY x DA) x WKY population, for which the DA rat is a nonsusceptible control strain. We found two significant QTLs on chromosomes 1 and 12, which were involved in elevated levels of proteinuria and kidney weight index, respectively. The relevance of these QTLs with the genetic factors involved in autoimmunity and renal disease is discussed.


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CRRD Object Information
CRRD ID: 2312387
Created: 2009-08-11
Species: All species
Last Modified: 2009-08-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.