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A-kinase anchoring proteins: from protein complexes to physiology and disease.

Authors: Carnegie, GK  Means, CK  Scott, JD 
Citation: Carnegie GK, etal., IUBMB Life. 2009 Apr;61(4):394-406.
Pubmed: (View Article at PubMed) PMID:19319965
DOI: Full-text: DOI:10.1002/iub.168

Protein scaffold complexes are a key mechanism by which a common signaling pathway can serve many different functions. Sequestering a signaling enzyme to a specific subcellular environment not only ensures that the enzyme is near its relevant targets, but also segregates this activity to prevent indiscriminate phosphorylation of other substrates. One family of diverse, well-studied scaffolding proteins are the A-kinase anchoring proteins (AKAPs). These anchoring proteins form multi-protein complexes that integrate cAMP signaling with other pathways and signaling events. In this review, we focus on recent advances in the elucidation of AKAP function.


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CRRD Object Information
CRRD ID: 2312477
Created: 2009-08-19
Species: All species
Last Modified: 2009-08-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.