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cGMP-phosphodiesterase activity is up-regulated in response to pressure overload of rat ventricles.

Authors: Yanaka, N  Kurosawa, Y  Minami, K  Kawai, E  Omori, K 
Citation: Yanaka N, etal., Biosci Biotechnol Biochem. 2003 May;67(5):973-9.
Pubmed: (View Article at PubMed) PMID:12834273
DOI: Full-text: DOI:10.1271/bbb.67.973

Although expression of natriuretic peptides in cardiac tissues is up-regulated in response to pressure overload, no significant change in cGMP level in hypertrophied ventricles was observed. Activities of two cyclic nucleotide phosphodiesterase (PDE) isoforms, Ca2+/calmodulin-stimulated PDE (PDE1) and cGMP-stimulated PDE (PDE2), were significantly higher in rat left ventricles 14 days after aortic banding. The absence of significant changes in PDE1A and PDE2A mRNA levels indicated that the two PDE activities were post-transcriptionally up-regulated. These results suggested that the increased cGMP-PDE activity in response to pressure overload plays an important role in neutralizing cGMP action in cardiac tissue.


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CRRD Object Information
CRRD ID: 2312523
Created: 2009-08-20
Species: All species
Last Modified: 2009-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.