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Alternative wnt signaling is initiated by distinct receptors.

Authors: Van Amerongen, R  Mikels, A  Nusse, R 
Citation: van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
Pubmed: (View Article at PubMed) PMID:18765832
DOI: Full-text: DOI:10.1126/scisignal.135re9

An unanswered question in the field of signal transduction research is how different signaling pathways are activated with strict specificity in a temporally and spatially controlled manner. Because extracellular ligands and membrane receptors constitute the first signaling modalities for most pathways, selectivity in ligand-receptor binding likely dictates the outcome of downstream signaling events. Unfortunately, possible complexities underlying ligand-receptor interactions are often overlooked. Here, we discuss basic principles of signal transduction initiated at the cell membrane, with the Wnt pathway, which harbors a multitude of ligands and receptors, as an example.


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CRRD Object Information
CRRD ID: 2313743
Created: 2009-10-13
Species: All species
Last Modified: 2009-10-13
Status: ACTIVE


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