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PI3K/Akt: getting it right matters.

Authors: Franke, TF 
Citation: Franke TF Oncogene. 2008 Oct 27;27(50):6473-88.
Pubmed: (View Article at PubMed) PMID:18955974
DOI: Full-text: DOI:10.1038/onc.2008.313

The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical signaling molecule within eukaryotic cells. Significant progress has been made in clarifying its regulation by upstream kinases and identifying downstream mechanisms that mediate its effects in cells and contribute to signaling specificity. Here, we provide an overview of present advances in the field regarding the function of Akt in physiological and pathological cell function within a more generalized framework of Akt signal transduction. An emphasis is placed on the involvement of Akt in human diseases ranging from cancer to metabolic dysfunction and mental disease.

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CRRD Object Information
CRRD ID: 2313763
Created: 2009-10-14
Species: All species
Last Modified: 2009-10-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.