Increased Ceruloplasmin and Fibrinogen in Type 2 Diabetes Corresponds to Decreased Anti-oxidant Activity in a Preliminary Tertiary South Indian Hospital Study.

Authors: Chacko, SK  Cheluvappa, R 
Citation: Chacko SK and Cheluvappa R, Exp Clin Endocrinol Diabetes. 2009 Oct 15.
Pubmed: (View Article at PubMed) PMID:19834873
DOI: Full-text: DOI:10.1055/s-0029-1225647

The relationship between type 2 diabetes, antioxidant-enzyme serum ceruloplasmin, pro-inflammatory blood fibrinogen and antioxidant activity (AOA) was investigated in 40 diabetics and 47 non-diabetics hailing from South India as a preliminary study aspiring to be a crucial stepping stone for a large study. Serum AOA was lower (p<0.01) in diabetics (0.68+/-0.03 mmol/L) than controls (0.92+/-0.07 mmol/L) and ceruloplasmin more (p<0.001) in diabetics (983.20+/-52.18 mg/L) than controls (470.79+/-39.20 mg/L). Plasma fibrinogen was higher (p<0.001) in diabetics (480.23+/-19.52 mg/dl) than controls (313.94+/-13.42 mg/dl). Males had more AOA. Fibrinogen increased with age. These significant findings point strongly to augmented oxidative stress and inflammatory states in South Indian diabetics.


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CRRD Object Information
CRRD ID: 2314681
Created: 2009-11-23
Species: All species
Last Modified: 2009-11-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.