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Growth and developmental regulation of wnt-2 (irp) gene in mesenchymal cells of fetal lung.

Authors: Levay-Young, BK  Navre, M 
Citation: Levay-Young BK and Navre M, Am J Physiol. 1992 Jun;262(6 Pt 1):L672-83.
Pubmed: (View Article at PubMed) PMID:1377452

The wnt gene family encodes a group of proteins implicated as intercellular signaling molecules in vertebrate development. Because many wnt genes are also expressed in the lung, we have examined whether the wnt family member wnt-2 (irp) plays a role in lung development. We have cloned rat wnt-2 and found that this cDNA detects multiple mRNAs expressed at high levels in fetal rat lung. Much lower levels were found in adult rat lung and other tissues, including, surprisingly, the mammary gland. The wnt-2 mRNA was also detected in human fetal lung fibroblast cell lines, where the mRNA levels were dramatically regulated by growth state as well as growth factor stimulation. In situ hybridization showed that, in fetal rat lung, wnt-2 mRNA expression is restricted to the mesenchyme; levels in the developing epithelium were indistinguishable from background. Based on the known properties of other wnt proteins, our data lead us to propose that wnt-2 may play a role in lung development by mediating intercellular interaction(s) between mesenchyme and epithelium.

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CRRD Object Information
CRRD ID: 2314905
Created: 2009-12-08
Species: All species
Last Modified: 2009-12-08
Status: ACTIVE



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