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Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer.

Authors: Yoshida, H  Cheng, W  Hung, J  Montell, D  Geisbrecht, E  Rosen, D  Liu, J  Naora, H 
Citation: Yoshida H, etal., Proc Natl Acad Sci U S A. 2004 May 25;101(21):8144-9. Epub 2004 May 14.
Pubmed: (View Article at PubMed) PMID:15146066
DOI: Full-text: DOI:10.1073/pnas.0400400101

Dissemination of ovarian cancer is a major clinical challenge and is poorly understood at the molecular level due to a lack of suitable experimental models. During normal development of the Drosophila ovary, a dynamic process called border cell migration occurs that resembles the migratory behavior of human ovarian cancer cells. In this study, we found that myosin VI, a motor protein that regulates border cell migration, is abundantly expressed in high-grade ovarian carcinomas but not in normal ovary and ovarian cancers that behave indolently. Inhibiting myosin VI expression in high-grade ovarian carcinoma cells impeded cell spreading and migration in vitro. Optical imaging and histopathologic studies revealed that inhibiting myosin VI expression reduces tumor dissemination in nude mice. Therefore, using genetic analysis of border cell migration in Drosophila is a powerful approach to identify novel molecules that promote ovarian cancer dissemination and represent potential therapeutic targets.


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CRRD Object Information
CRRD ID: 2314958
Created: 2009-12-10
Species: All species
Last Modified: 2009-12-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.