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Effect of cocaine on the histaminergic neuron system in the rat brain.

Authors: Ito, C  Onodera, K  Sakurai, E  Sato, M  Watanabe, T 
Citation: Ito C, etal., J Neurochem. 1997 Aug;69(2):875-8.
Pubmed: (View Article at PubMed) PMID:9231750

To examine the effect of cocaine on the brain histamine neuron system, histamine levels and histamine N-methyltransferase activity in the rat brain were measured after the administration of cocaine. Moreover, we examined the effect of L-histidine on cocaine-induced wheel-running behavior. The administration of cocaine (20 mg/kg) increased histamine levels and histamine N-methyltransferase activity in the striatum, nucleus accumbens, and amygdala 1 h later. The pretreatment with L-histidine (350 and 700 mg/kg) inhibited the cocaine (20 mg/ kg)-induced increase of wheel-running activity in a dose-dependent manner. These findings suggest that cocaine activates the brain histamine neuron system, which may play the role of inhibiting the cocaine-induced wheel-running behavior.

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CRRD Object Information
CRRD ID: 2316833
Created: 2010-03-01
Species: All species
Last Modified: 2010-03-01
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.